Thuốc Dextromethorphan 0.2% Bvp Là Gì?
Thuốc Dextromethorphan 0.2% Bvp, chứa dược chất chính là dextromethorphan là thuốc giảm ho, có tác dụng lên trung tâm ho ở hành não.
Thành Phần Của Thuốc Dextromethorphan 0.2% Bvp
Công Dụng Của Thuốc Dextromethorphan 0.2% Bvp
Chỉ định
Thuốc Dextromethorphan được chỉ định dùng trong các trường hợp sau:
- Ðiều trị ho khan mãn tính.
- Điều trị ho khan cấp tính kiên quan đến sự kích thích khi cảm lạnh thông thường hoặc khi hít phải chất kích thích.
Dược lực học
Dextromethorphan hydrobromid là chất giảm ho có tác dụng lên trung tâm ho ở hành não.
Mặc dù cấu trúc hóa học có liên quan đến morphin, nhưng dextromethorphan không có tác dụng giảm đau và nói chung rất ít có tác dụng an thần.
Dextromethorphan được dùng giảm ho nhất thời do kích thích nhẹ ở phế quản và họng như cảm lạnh thông thường hoặc hít phải các chất kích thích.
Dextromethorphan có hiệu quả nhất trong điều trị ho mạn tính, không có đờm. Thuốc không có tác dụng long đờm. Hiệu lực của dextromethorphan gần tương đương với hiệu lực của codein nhưng ít gây tác dụng phụ ở đường tiêu hóa hơn. Với liều điều trị, tác dụng chống ho của thuốc kéo dài được 5 - 6 giờ.
Độc tính thấp, không gây nghiện, nhưng với liều rất cao có thể gây ức chế hệ thần kinh trung ương.
Dược động học
Dextromethorphan được hấp thu nhanh qua đường tiêu hóa và có tác dụng trong vòng 15 - 30 phút sau khi uống, kéo dài khoảng 6 - 8 giờ. Thuốc được chuyển hóa ở gan và bài tiết qua nước tiểu dưới dạng không đổi và các chất chuyển hóa demethyl, trong số đó có dextrophan cũng có tác dụng giảm ho nhẹ.
Liều Dùng Của Thuốc Dextromethorphan 0.2% Bvp
Cách dùng
Thuốc Dextromethorphan được dùng đường uống. Lắc kỹ chai thuốc trước khi dùng.
Liều dùng
Người lớn và trẻ em trên 12 tuổi: Uống 5ml - 10ml mỗi 4 giờ 1 lần hay uống 15ml mỗi 6 - 8 giờ 1 lần. Liều tối đa 60ml trong 24 giờ.
Trẻ em từ 6 - 12 tuổi: Uống 2,5ml - 5 ml mỗi 4 giờ 1 lần hay uống 7,5 mỗi 6 - 8 giờ 1 lần. Liều tối đa 30ml trong 24 giờ.
Trẻ em từ 2 đến 6 tuổi: Uống 1,25 - 2,5ml mỗi 4 giờ 1 lần hay uống 3,75ml mỗi 68 giờ 1 lần. Liều tối đa 15ml trong 24 giờ.
Trẻ em dưới 2 tuổi không dùng.
Lưu ý: Liều dùng trên chỉ mang tính chất tham khảo. Liều dùng cụ thể tùy thuộc vào thể trạng và mức độ diễn tiến của bệnh. Để có liều dùng phù hợp, bạn cần tham khảo ý kiến bác sĩ hoặc chuyên viên y tế.
Làm gì khi dùng quá liều?
Triệu chứng quá liều gồm
Buồn nôn, nôn, buồn ngủ, nhìn mờ, rung giật nhãn cầu, bí tiểu tiện, trạng thái tê mê, ảo giác, mất điều hòa, suy hô hấp, co giật.
Xử trí
Hỗ trợ dùng naloxon 2mg tiêm tĩnh mạch, cho dùng nhắc lại nếu cần tới tổng liều 10mg.
Làm gì khi quên 1 liều?
Dextromethorphan thường chỉ được sử dụng khi cần thiết. Nếu bác sĩ yêu cầu bạn uống dextromethorphan thường xuyên mà bạn bỏ quên liều, dùng liều đó ngay khi nhớ ra.
Tuy nhiên, khi bỏ quên liều mà đã gần tới thời gian uống liều tiếp theo bạn có thể bỏ qua liều đã quên và tiếp tục lịch trình dùng thuốc của bạn. Không dùng liều gấp đôi để bù cho liều bỏ lỡ.
Tác Dụng Phụ Của Thuốc Dextromethorphan 0.2% Bvp
Khi sử dụng thuốc Dextromethorphan, bạn có thể gặp các tác dụng không mong muốn (ADR).
- Mệt mỏi, buồn nôn, chóng mặt, nhịp tim nhanh, đỏ da. Ít khi bị nổi mề đay.
- Thỉnh thoảng thấy buồn ngủ nhẹ, rối loại tiêu hóa.
- Dùng liều cao có thể gây ngộ độc có hành vi kỳ quặc, ức chế thần kinh trung ương và suy hô hấp.
Hướng dẫn cách xử trí ADR
Khi gặp tác dụng phụ của thuốc, cần ngưng sử dụng và thông báo cho bác sĩ hoặc đến cơ sở y tế gần nhất để được xử trí kịp thời.
Lưu Ý Của Thuốc Dextromethorphan 0.2% Bvp
Trước khi sử dụng thuốc bạn cần đọc kỹ hướng dẫn sử dụng và tham khảo thông tin bên dưới.
Chống chỉ định
Thuốc Dextromethorphan chống chỉ định trong các trường hợp sau:
- Quá mẫn cảm với bất cứ thành phần nào của thuốc.
- Trẻ em dưới 2 tuổi.
- Người có các bệnh lý gây ức chế hô hấp.
- Dùng kết hợp với các chất ức chế monoamin oxidase.
- Người có bệnh gan.
Thận trọng khi sử dụng
Người bị ho có nhiều đờm và ho mạn tính ở người hút thuốc, hen hoặc tràn khí.
Người có nguy cơ hoặc đang bị suy hô hấp.
Trẻ em bị dị ứng, do liên quan đến giải phóng histamine.
Lạm dụng và phụ thuộc dextromethorphan có thể xảy ra (tuy hiếm) đặc biệt do dùng liều cao kéo dài.
Thuốc không chứa đường saccharose, có thể dùng được cho người bị đái thái đường.
Khả năng lái xe và vận hành máy móc
Dùng thuốc thận trọng cho người lái xe hoặc vận hành máy móc.
Thời kỳ mang thai
Nên tránh sử dụng thuốc này cho phụ nữ trong thời kỳ mang thai.
Thời kỳ cho con bú
Nên tránh sử dụng thuốc này cho phụ nữ trong thời kỳ cho con bú.
Tương tác thuốc
Tránh dùng đồng thời với các thuốc IMAO.
Quinidin ức chế Cytochrom P450 2D6 có thể làm giảm chuyển hóa dextromethorphan ở gan, làm tăng nồng độ chất này trong máu và tăng tác dụng phụ của thuốc.
Dùng đồng thời với các thuốc ức hế thần kinh trung ương có thể tăng cường tác dụng ức chế thần kinh trung ương của những thuốc này hoặc của dextromethorphan.
Bảo Quản
Nhiệt độ không quá 30oC, tránh ánh sáng.
Nguồn Tham Khảo
Tờ Hướng dẫn sử dụng thuốc Dextromethorphan 0.2% Bvp.
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